《Pharmaceutical-dosage-forms-Parenteral-medications-Vol-1-Formulation-and-packaging》关于注射液处方前溶解度研究有如下一段表述:
In determining equilibrium solubility, it is important to ascertain that (i) an asymptotic value has been achieved (constant over multiple time-points) and (ii) the identity of the solid in contact with the solvent is unchanged. The identity of the residual phase can be confirmed by analyzing the residue using techniques such as differential scanning calorimetry (DSC) or X-ray powder diffractometry (XRPD).
请问对于饱和溶解度测定时,未溶解部分的样品一般是否测定其晶型?又或者说如何根据具体品种特点去评估是否需要测定?谢谢