DNA tags help the hunting for drug-药物发现

小刚刚

Drug discovery is a daunting process that requires chemists to sift through millions of chemicals to find a single hit. DNA Encoded library can dramatically speed up the search.
DNA-encoded libraries were first proposed in 1992, in a thought experiment  by molecular biologist Sydney Brenner and chemist Richard Lerner, who were then at the Scripps Research Institute in La Jolla, California.
Incubate the active immobilized target protein and DELs for some time; during the time, compounds with strong affinity will bind to the protein while non-bind or weak-bind compounds will be eluted. Heat up to inactive the protein and elute the binding compounds. Through PCR amplification technology, we can read the DNA tags of the binding compounds and then chemical information of the hit compounds can be obtained. After activity assay and chemical structure optimization, lead compounds are generated.
Now the most advanced compound to emerge from GSK’s DNA-encoded library so far is GSK2256294 in PhI (the inhibitor of Pulmonary Disease and Chronic Obstructive). Except GSK，HitGen, in Chengdu, China , is also a member of DEL family and has synthesized more than 6 billion DNA Encoded Compounds.
DNA Encoded Libraries come of age.
The following picture is  GSK2256294 in PhI (the inhibitor of Pulmonary Disease and Chronic Obstructive)

静水蓝心

感谢分享

syhorchid

学习一下

胜利者

飘过

小刚刚

静水蓝心 发表于 2016-11-25 12:15
感谢分享

不客气，一般我读了之后会放到微信群里分享给群友，只是觉得应该大家一起分享才放到网上的

小刚刚

syhorchid 发表于 2016-11-25 18:10
学习一下

看样子都是药圈儿中人呀

小刚刚

胜利者 发表于 2016-11-25 18:43
飘过

文章还是很有意义的，需要多读几遍

静水蓝心

小刚刚 发表于 2016-11-29 10:36
不客气，一般我读了之后会放到微信群里分享给群友，只是觉得应该大家一起分享才放到网上的

英文不错啊